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</a> Melanoma is the least common but the most lethal of skin cancers. Accounting for 75 percent of all skin-cancer deaths, melanoma originates in pigment-producing skin cells called melanocytes. Melanoma is believed to be a multistep process (melanomagenesis) of genetic mutations that increase cell proliferation, cell differentiation and cell death and increase an individual&rsquo;s susceptibility to ultraviolet (UV) radiation. Two types of UV radiation&mdash;UVA and UVB&mdash;can mutate DNA in skin cells and lead to melanoma.